CACLP - The largest IVD Expo & Conference

How Immune Response Against Viruses Is Driven by Key Protein

Industry news | 11 January, 2022 | CACLP

Original from: Technology Network


Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defence against viruses. They hope this discovery will help them one day better control the response to either boost it or calm it down as appropriate.


The scientists behind the discovery include Andrew Bowie, Professor of Innate Immunology at Trinity College Dublin, who is based in the Trinity Biomedical Sciences Institute, and Drs Lili Gu and David Casserly (formerly at Trinity as postdoctoral and PhD researchers respectively).


Their findings, which provide a target for new therapies that could improve anti-viral responses in some patients and reduce autoimmune problems in others when immune responses run out of control, have just been published in leading journal Nature Communications. 

Interferons and MNDA – a major piece of the puzzle

“Interferons” are key proteins that tell our immune systems when viruses, germs or cancer cells are in our bodies. Type I interferons are produced when the innate immune system senses the presence of a virus. In such circumstances interferons trigger a complex chain of events in which other cells are kicked into gear to “interfere with” and fight those invaders.


Scientists don’t fully understand how certain links in that chain of events are controlled—making it difficult to stimulate or suppress an immune response with therapeutic interventions—but this new research has provided key new insights into the process.


The scientists have discovered that another protein, myeloid cell nuclear differentiation antigen (MNDA), is needed for Type I interferon production from human blood cells in response to viruses. Their work shows that MNDA regulates a transcription factor, IRF7, which in essence drives Type I interferon production.


Professor Andrew Bowie said: 


“We have been interested in better understanding how Type I interferons are produced from blood cells because they are required to fight viruses, and because too much of them—when the production process runs out of control, for example—contributes to nasty autoimmune diseases such as interferonopathies.


“There is a family of proteins called PYHIN proteins which we have been working on for some time, as they are implicated in regulating innate immunity. To our surprise, one such PYHIN protein, called MNDA, turned out to be a big missing piece in the puzzle in understanding how type I interferon production is sustained, which makes this discovery all the more exciting. 


“If we can learn how to manipulate MNDA's activity it could be really beneficial – on one hand to boost an interferon response during a viral infection, for example upon COVID-19 infection, or on the other hand to supress interferon production and treat an autoimmune disorder.” 


The scientists are currently examining how MNDA contributes to innate immune responses to COVID-19.


Source: How Immune Response Against Viruses Is Driven by Key Protein

Filed under:
Press contact CACLP - The largest IVD Expo & Conference

Stay in touch with CACLP News

We deliver the latest IVD news straight to your inbox. Stay in touch with CACLP News, sign-up for our newsletter today.

  • Name *
  • Email *
  • Company name *
  • Country *
    CACLP - The largest IVD Expo & Conference

By subscribing our newsletter, you agree to our Privacy Policy. You can unsubscribe at anytime.

Share
Opening Countdown
0 0 0

Day(s)

0 0

Hour(s)

0 0

Min(s)

Room 2201-2203 & 2205, Cloud Nine Plaza
1118 West Yan’an Road
Shanghai, China
200052

Copyright © 2024 GL events Ruihe (Shanghai) Exhibition Co., Ltd. All Rights Reserved. ( 沪ICP备12004745号-1 )

We use cookies to help provide you with the best possible online experience. Please read our Privacy Policy & Cookies for information about which cookies we use and what information we collect on our site. By continuing to use this site, you agree that we may store and access cookies on your device.

CACLP - The largest IVD Expo & Conference