In Vitro Diagnostic Industry in China - Molecular Diagnosis Analyzers and Reagents XX

3.4 Genetic Disease Molecular Diagnostic Reagents

3.4.1 Preimplantation Screening Reagent

In vitro fertilization embryos are prone to chromosomal aneuploidy abnormalities. Chromosome aneuploidy refers to the increase or decrease in the number of a single chromosome or multiple chromosomes. It is the most common chromosome number abnormality in clinical practice. The implantation of embryos with abnormal chromosomes into a woman’s uterus can lead to implantation failure, abortion, birth defects, and other problems. Preimplantation genetic testing for aneuploidies (PGT-A) reduces the probability of implantation of embryos with chromosomal abnormalities. Thus, it reduces the number of repeated implantation failures, repeated abortions, birth defects, and other problems caused by the implantation of embryos with chromosomal abnormalities. Common techniques for detecting chromosomal aneuploidy include fluorescence in situ hybridization (FISH) and comparative genomic hybridization (Array-CGH) and single nucleotide polymorphism (SNP array).

Suzhou Basecare Medical Co. Ltd. developed a preimplantation genetic testing kit for aneuploidies (Registration Number: G.X.Z.Z. 20,203,400,181) using high-throughput sequencing technology to analyze whether there is an abnormal number of aneuploidies in the embryo chromosome. DNA detection of some cells of this embryo can assist clinicians to judge whether the embryo is implanted.

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